Trifluoroacetic acid → 4-(2-Chlorophenylamino)-5,6-difluoro-1,2-dihydroindazol-3-one

HRID 1723694노트

반응식

HRID 1723694 반응식
COC(=O)[C:4]1[C:9]([NH:10][NH:11][C:12](OC(C)(C)C)=[O:13])=[CH:8][C:7]([F:19])=[C:6]([F:20])[C:5]=1[NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[Cl:28].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[NH:21][C:5]1[C:6]([F:20])=[C:7]([F:19])[CH:8]=[C:9]2[C:4]=1[C:12](=[O:13])[NH:11][NH:10]2

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 865985976-(N'-tert-Butoxycarbonylhydrazino)-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester

생성물 1

HCID 674033074-(2-Chlorophenylamino)-5,6-difluoro-1,2-dihydroindazol-3-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

6-(N′-tert-Butoxycarbonylhydrazino)-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester (1.00 equivalent) is treated with a 1:1 mixture of methylene chloride and TFA and stirred for 2 hours The reaction mixture is concentrated under reduced pressure and the product is purified by trituration or flash column chromatography if needed.

후처리

  1. concentrationis concentrated under reduced pressure
  2. customthe product is purified by trituration or flash column chromatography

출처 및 근거

ORD 기록
ord-f465b05b652b48fc9d63acece16c8913
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07485643B2

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