참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ziprasidone | HCID 60854 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Ziprasidone Hydrochloride | HCID 219099 | — |
반응 단계
Ziprasidone (5 g) and 50 mL of acetic acid were placed into a round bottom flask and heated to 45-50° C. Added was 25 mL of aqueous hydrochloric acid slowly to the mixture over 20 min. Then the reaction mixture was refluxed. Water (10 mL) was added, followed by addition of 50 mL of Isopropanol. The reaction mass was cooled to 50° C. and distilled off the solvent completely under vacuum. The material formed was scratched from the flask.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07488729B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_02 |
|---|
| ORD ID | ord-9e5bbee97d30450b80ddca42bd2496c4 |
|---|
| 출처 메모 | uspto-grants-2009_02 |
|---|
