2-Bromoethyl methyl ether → HCID 11633398, 화합물

HRID 1724908노트

반응식

HRID 1724908 반응식
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[CH3:23][O:24][CH2:25][CH2:26][Br:27]>CC#N>[Br-:27].[OH:10][C:9]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:5][CH2:6][N+:1]([CH2:26][CH2:25][O:24][CH3:23])([CH2:2][CH2:3]1)[CH2:8][CH2:7]2

참가 물질

4

반응물 2

HCID 809722-Bromoethyl methyl etherHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

생성물 1

HCID 11633398HCID 11633398, 화합물수율 42.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0597 g, 0.203 mmol) and 2-bromoethyl methyl ether (0.030 mL, 0.319 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0372 g, 42.8%). EI-MS m/z 352(M+) Rt (1.69 min).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-dc5a3410c91e4d1d80ee0a4727624d9f
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07488827B2

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