[1-(Cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester → 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide

HRID 1725195

반응식

HRID 1725195 반응식
C(OC(=O)[NH:7][C:8]1([CH:11]([C:13](=[O:18])[NH:14][CH:15]2[CH2:17][CH2:16]2)[OH:12])[CH2:10][CH2:9]1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:7][C:8]1([CH:11]([OH:12])[C:13]([NH:14][CH:15]2[CH2:16][CH2:17]2)=[O:18])[CH2:10][CH2:9]1

참가 물질

4

반응물 1

HCID 67385903[1-(Cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester

생성물 1

HCID 575620962-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of [1-(cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester in CH2Cl2 (5 mL) and TFA (5 mL) was stirred at room temperature for 2.5 h. The reaction mixture was concentrated and chased with toluene to yield 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide.

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-383fcd2de2b64a1182f52250e8ef12e0
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07488848B2

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