Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylcarbodiimide → {2-[2-({2-[2-(3,4,5,6-Tetraacetoxy-7-hydroxy-2-oxo-heptyloxy)ethoxy]ethylcarbamoyl}methoxy)ethoxy]ethoxy}acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylcarbodiimide | HCID 12734 | — |
| 반응물 | 3,6,9-Trioxaundecanedioic acid | HCID 83793 | — |
| 반응물 | 2,3,4-Triacetoxy-1-{2-[2-(2-aminoethoxy)ethoxy]acetyl}-5-hydroxypentyl acetate | HCID 23593511 | — |
| 반응물 | HCID 178418300 | HCID 178418300 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | {2-[2-({2-[2-(3,4,5,6-Tetraacetoxy-7-hydroxy-2-oxo-heptyloxy)ethoxy]ethylcarbamoyl}methoxy)ethoxy]ethoxy}acetic acid | HCID 22252083 | — |
반응 단계
A solution of 500 mg of 2,3,4-triacetoxy-1-{2-[2-(2-aminoethoxy)ethoxy]acetyl}-5-hydroxypentyl acetate 23, 1.15 g of [2-(2-carboxymethoxyethoxy)ethoxy]acetic acid, 400 μl of diisopropylcarbodiimide and 288 mg of hydroxybenzotriazole in 20 ml of methylene chloride is stirred at room temperature for 12 h. The reaction solution is concentrated and separated by HPLC (Knauer Eurospher-100-10-C18, water (0.1% trifluoroacetic acid)/acetonitrile (0.1% trifluoroacetic acid)=80/20->10/90). This gives 24: C28H45NO18 (683.67) MS (ESI) 684 (M+H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07488829B2 |
| 출처 데이터셋 | uspto-grants-2009_02 |
| ORD ID | ord-6946e11093b5492c92d706079ba41ef3 |
| 출처 메모 | uspto-grants-2009_02 |