1,1'-Carbonyldiimidazole → HCID 68843504, 화합물

HRID 1725348노트

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HRID 1725348 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([F:32])[CH:31]=1)[O:5][CH2:6][CH2:7][N:8]([CH3:28])[CH2:9][CH2:10][CH2:11][NH:12][CH2:13][C@@H:14]([C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH3:27])[CH:24]=2)[N:19]=[CH:18][CH:17]=1)[OH:15].[C:33](N1C=CN=C1)(N1C=CN=C1)=[O:34]>C(Cl)Cl>[F:32][C:30]1[CH:29]=[C:4]([CH:3]=[C:2]([F:1])[CH:31]=1)[O:5][CH2:6][CH2:7][N:8]([CH3:28])[CH2:9][CH2:10][CH2:11][N:12]1[CH2:13][C@@H:14]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH3:27])[CH:24]=3)[N:19]=[CH:18][CH:17]=2)[O:15][C:33]1=[O:34]

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 44535577(I+/-R)-I+/--[[[3-[[2-(3,5-Difluorophenoxy)ethyl]methylamino]propyl]amino]methyl]-6-methoxy-4-quinolinemethanol

생성물 1

HCID 68843504HCID 68843504, 화합물수율 62%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of (R)-2-(3-{[2-(3,5-difluoro-phenoxy)-ethyl]-methyl-amino}-propylamino}-1-(6-methoxy-quinolin-4-yl)-ethanol (105 mg, 0.24 mmol), DMAP-(38 mg, 0.31 mmol), 1,1′-carbonyldiimidazole (51 mg, 0.31 mmol) and methylene chloride stabilised on amylene (4 ml) was stirred at room temperature for 16 hours. The solvent was concentrated and the residue was chromatographed on silicagel eluting with methylene chloride-methanol (94-6) to give (R)-3-(3-{[2-(3,5-difluoro-phenoxy)-ethyl]-methyl-amino)-propyl)-5-(6-methoxy-quinolin-4-yl)-oxazolidin-2-one (70 mg, 62%).

후처리

  1. concentrationThe solvent was concentrated
  2. customthe residue was chromatographed on silicagel
  3. washeluting with methylene chloride-methanol (94-6)

출처 및 근거

ORD 기록
ord-886f468c26714823bf32312429299622
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07491714B2

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