Chlorosuccinimide → 6-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-(5-chlorothiazol-2-yl)pyridin-2-amine

HRID 1725479노트

반응식

HRID 1725479 반응식
[Si:1]([O:8][CH2:9][C:10]1[N:15]=[C:14]([NH:16][C:17]2[S:18][CH:19]=[CH:20][N:21]=2)[CH:13]=[CH:12][CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[Cl:22]N1C(=O)CCC1=O>O1CCOCC1.C(OCC)(=O)C>[Si:1]([O:8][CH2:9][C:10]1[N:15]=[C:14]([NH:16][C:17]2[S:18][C:19]([Cl:22])=[CH:20][N:21]=2)[CH:13]=[CH:12][CH:11]=1)([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:2])[CH3:3]

참가 물질

5

반응물 2

HCID 31398ChlorosuccinimideHCID 57562580HCID 57562580, 화합물

생성물 1

HCID 575626076-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-(5-chlorothiazol-2-yl)pyridin-2-amine

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 312751,4-Dioxane용매

실험 절차

2 g of 6-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-thiazol-2-ylpyridin-2-amine obtained in Example 5-(2) was dissolved in 20 ml of 1,4-dioxane, and then 832 mg of N-chlorosuccinimide was added thereto at room temperature. The reaction mixture was heated under reflux for 2 hours, cooled to room temperature, diluted with ethyl acetate, and then washed with water and brine. The resulting organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated in vacuo to give the title compound.

후처리

  1. customat room temperature
  2. temperatureThe reaction mixture was heated
  3. temperatureunder reflux for 2 hours
  4. washwashed with water and brine
  5. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-b86519f04cc64dc4874860a435bde1f9
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07491720B2

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