Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Methyl 5-nitroquinoline-8-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Nitroquinoline-8-carboxylic acid | HCID 15405331 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 5-nitroquinoline-8-carboxylate | HCID 68521805 | 78.4% |
반응 단계
To a stirred solution of 300 mg (1.375 mmol) of 5-nitroquinoline-8-carboxilic acid (Breckenridge, J. G. Et al., Canadian J. of Research Sect. B; 1947, 25, 49) in DMF (6 mL), 546 mg (3.850 mmol) of iodomethane and 190 mg (1.375 mmol) of potassium carbonate were added. The resulting mixture was stirred at room temperature for one hour. Water (10 mL) was added and the product collected by filtration. The residue was washed with water and dried to yield the title compound (250 mg, 78.4%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07491722B2 |
| 출처 데이터셋 | uspto-grants-2009_02 |
| ORD ID | ord-5ee214cf2dbe45b78e8225f89264efb3 |
| 출처 메모 | uspto-grants-2009_02 |