2-Amino-5-nitropyridine → 5-Acetyl-2-ethyl-4-[(5-nitropyridin-2-yl)amino]-6-phenylpyridazin-3(2H)-one

HRID 1725524

반응식

HRID 1725524 반응식
[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[N+:19]([O-])=O)(=[O:3])[CH3:2].N[C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][N:24]=1>C(O)C>[C:1]([C:4]1[C:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[NH:19][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][N:24]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 778882-Amino-5-nitropyridineHCID 107320155-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one

생성물 1

HCID 684856525-Acetyl-2-ethyl-4-[(5-nitropyridin-2-yl)amino]-6-phenylpyridazin-3(2H)-one수율 34.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 80 mg (0.278 mmol) of 5-acetyl-2-ethyl-4-nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) in 4 ml of ethanol, 77 mg (0.556 mmol) of 2-amino-5-nitropyridine was added. The resulting mixture was irradiated in microwave oven for seven hours at 120° C. The final product was collected by filtration and washed with diethylether to yield the title compound (36 mg, 34.3% yield).

후처리

  1. customThe resulting mixture was irradiated in microwave oven for seven hours at 120° C
  2. filtrationThe final product was collected by filtration
  3. washwashed with diethylether

출처 및 근거

ORD 기록
ord-67dbdc8ca383432ba7cf92a6e4da058c
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07491722B2

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