Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-indazol-7-amine → 5-Acetyl-2-ethyl-4-(1H-indazol-7-ylamino)-6-phenylpyridazin-3(2H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-indazol-7-amine | HCID 88901 | — |
| 반응물 | 5-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one | HCID 10732015 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Acetyl-2-ethyl-4-(1H-indazol-7-ylamino)-6-phenylpyridazin-3(2H)-one | HCID 68488302 | 86.7% |
반응 단계
To a stirred solution of 80 mg (0.278 mmol) of 5-acetyl-2-ethyl-4-nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) in ethanol (4 mL), 1H-indazol-7-amine (56 mg, 0.417 mmol) was added. The resulting mixture was stirred at room temperature during one hour and the final product was collected by filtration and washed with diethylether to yield the title compound (90 mg, 86.5% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07491722B2 |
| 출처 데이터셋 | uspto-grants-2009_02 |
| ORD ID | ord-2f21093a501f4327b590125a11487d48 |
| 출처 메모 | uspto-grants-2009_02 |