3-Amino-5-methylisoxazole → 5-Acetyl-2-ethyl-4-[(5-methylisoxazol-3-yl)amino]-6-phenylpyridazin-3(2H)-one

HRID 1725542

반응식

HRID 1725542 반응식
[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[N+:19]([O-])=O)(=[O:3])[CH3:2].N[C:23]1[CH:27]=[C:26]([CH3:28])[O:25][N:24]=1>C(O)C>[C:1]([C:4]1[C:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[NH:19][C:23]1[CH:27]=[C:26]([CH3:28])[O:25][N:24]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 661723-Amino-5-methylisoxazoleHCID 107320155-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one

생성물 1

HCID 684884685-Acetyl-2-ethyl-4-[(5-methylisoxazol-3-yl)amino]-6-phenylpyridazin-3(2H)-one수율 37.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of 80 mg (0.278 mmol) of 5-acetyl-2-ethyl nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al., J. Med. Chem. 1997, 40, 1417) in ethanol (4 mL), 3-amino-5-methylisoxazol (96 mg, 0.978 mmol) was added. The resulting mixture was stirred, at room temperature for four days and the final product was collected by filtration and washed with diethylether to yield the title compound (35 mg, 37.2% yield).

후처리

  1. filtrationthe final product was collected by filtration
  2. washwashed with diethylether

출처 및 근거

ORD 기록
ord-ca5665ef37d84a5b8462c7b3679d20f7
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07491722B2

연결된 노트

불러오는 중…