Thiazole → 4-(1,3-Thiazol-2-yl)piperidine hydrochloride

반응식

[ClH:1].Cl.[NH:3]1[CH:7]=[CH:6]N=[C:4]1[CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[S:14]1C=CN=C1>>[ClH:1].[S:14]1[CH:6]=[CH:7][N:3]=[C:4]1[CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

참가 물질

반응물 2

HCID 9256Thiazole

HCID 132811914-(1H-Imidazol-2-yl)piperidine dihydrochloride

생성물 1

HCID 687270984-(1,3-Thiazol-2-yl)piperidine hydrochloride

실험 절차

Prepared similarly as in the case of 4-(1H-imidazol-2-yl)piperidine dihydrochloride using 1,3-thiazole instead of 1-(diethoxymethyl)-1H-imidazole in Step A. 1H NMR (400 MHz, D2O): 8.24 (m, 1 H), 7.90(m, 1H), 3.77-3.68 (m, 1H), 3.57 (br. d, J=13 Hz, 2H), 3.19 (br. t, J=13 Hz, 2H), 2.42 (br. d, J=13 Hz, 21), 2.11-2.01 (m, 2H).

출처 및 근거

ORD 기록: ord-238570bed3714d9e8ace56ece2867932
출처 데이터셋: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07491737B2

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