Trimethylsilyldiazomethane → HCID 68862597, 화합물
반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[C:12]([OH:14])=[O:13].[CH3:15][Si](C=[N+]=[N-])(C)C>C1C=CC=CC=1.CO>[CH3:15][C:11]1[C:2]([NH2:1])=[C:3]([C:12]([OH:14])=[O:13])[C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2참가 물질
4
실험 절차
2-Amino-1-naphthoic acid (3.21 g, 17.2 mmol) in 4:1 benzene/CH3OH (125 mL) was treated with trimethylsilyldiazomethane (9.0 mL, 18.0 mmol, 2.0M solution in hexanes), stirred for 2.5 hours, quenched with acetic acid (0.5 mL), and concentrated. The concentrate was purified by flash column chromatography (4:1 hexanes/ethyl acetate) to provide the desired compound (3.25 g). MS (ESI(+)) m/e 202 (M+H)+; (ESI(−)) m/e 200 (M−H)−.
후처리
- customquenched with acetic acid (0.5 mL)
- concentrationconcentrated
- customThe concentrate was purified by flash column chromatography (4:1 hexanes/ethyl acetate)
출처 및 근거
- ORD 기록
- ord-7dc871bed0e2437c8bf18ae7a00d2045
- 출처 데이터셋
- uspto-grants-2009_02
- 특허 번호
- US07491718B2
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