Acetonitrile → 2-Phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine

HRID 1726363노트

반응식

HRID 1726363 반응식
C(#N)C.[Na].[CH2:5]([C:12]1[O:13][C:14](=O)[C:15](=[CH:17][OH:18])[N:16]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.Cl.[C:21]([NH2:29])(=[NH:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O>[C:22]1([C:21]2[NH:29][C:17](=[O:18])[C:15]([NH:16][C:12](=[O:13])[CH2:5][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=3)=[CH:14][N:28]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 80289Benzamidine, hydrochlorideHCID 178519094HCID 178519094, 화합물

생성물 1

HCID 116524352-Phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine수율 75.2%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

Acetonitrile (6 ml) was added to 2-benzyl-4-hydroxymethylene-5-oxazolone sodium salt (0.50 g, 2.22 mmol) and benzamidine hydrochloride (0.35 g, 2.22 mmol), and the mixture was stirred overnight at 80° C. Water (3 ml) was added, and the mixture was stirred. The precipitate was collected by filtration, and the obtained crystals were washed with water and vacuum dried to give 2-phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine (0.51 g, 1.67 mmol).

후처리

  1. stirringthe mixture was stirred
  2. filtrationThe precipitate was collected by filtration
  3. washthe obtained crystals were washed with water and vacuum
  4. customdried

출처 및 근거

ORD 기록
ord-ae925aba04ee43d7acd4cca4028f6894
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07491822B2

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