Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1726913생성일: 2026년 10월 25일
Potassium Carbonate → 3-(2-Chloro-5-nitro-phenyl)-1-methyl-7-methylsulfanyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
https://huagongshe.com/reaction/1726913
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | {5-[(2-Chloro-5-nitro-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl}-methyl-amine | HCID 68700288 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-(2-Chloro-5-nitro-phenyl)-1-methyl-7-methylsulfanyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one | HCID 68697893 | 96% |
반응 단계
20.796 g {5-[(2-Chloro-5-nitro-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl}-methyl-amine were dissolved in 500 ml acetonitrile, 25.375 g potassium carbonate and 19.847 g N,N-carbonyldiimidazole (CDI) were added, and the solution was heated at 50° C. for 24 hrs. The solvent was dried over sodium sulfate, evaporated, and the residue was extracted with diethyl ether to give the title product in 96% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07494993B2 |
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| 출처 데이터셋 | uspto-grants-2009_02 |
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| ORD ID | ord-d61fb5a9b9c64b76af8e83a9a25f797a |
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| 출처 메모 | uspto-grants-2009_02 |
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