2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde → [Rac]-1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol

HRID 1726969노트

반응식

HRID 1726969 반응식
[CH3:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[N:3]=1.[CH3:20][Mg]Cl>C1COCC1>[CH3:1][C:2]1[C:7]([CH:8]([OH:9])[CH3:20])=[CH:6][CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:17])([F:19])[F:18])=[CH:12][CH:11]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 219359652-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-3-carbaldehydeHCID 178418332HCID 178418332, 화합물

생성물 1

HCID 69035957[Rac]-1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

0.470 g (1.77 mmol) of the above prepared 2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde was dissolved in 9 ml of abs. THF and treated at −10° C. with 0.89 ml of 3M methyl magnesium chloride solution (in THF). After 15 Min., the reaction mixture was carefully poured onto crashed ice/NH4Cl, extracted twice with AcOEt, washed with water and brine, dried over sodium sulfate, and evaporated to dryness to leave 0.508 g of the title product, pure according to NMR.

후처리

  1. dissolutionwas dissolved in 9 ml of abs
  2. addition, the reaction mixture was carefully poured
  3. extractionextracted twice with AcOEt
  4. washwashed with water and brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-caacd75d1fc54eb8b0222727b40b0d14
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07495001B2

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