3-[4-(3-Benzyloxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamide → 3-[4-(3-Hydroxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamide

HRID 1727150노트

반응식

HRID 1727150 반응식
C([O:8][C:9]1[CH:10]=[C:11]([CH:15]2[CH2:19][N:18]([C:20]3[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=3)[C:23]([NH2:25])=[O:24])[C:17](=[O:29])[CH2:16]2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH:15]2[CH2:19][N:18]([C:20]3[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=3)[C:23]([NH2:25])=[O:24])[C:17](=[O:29])[CH2:16]2)[CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 1

HCID 575671163-[4-(3-Benzyloxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamide

생성물 1

HCID 688283783-[4-(3-Hydroxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamide수율 86.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 3-[4-(3-benzyloxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamide (1.2 g) in 50 mL EtOH was added 10% Pd/C (100 mg). The resulting mixture was stirred under H2 for 4 h, filtered, and concentrated under reduced pressure to give 0.8 g of crude product.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0976ff6980f54565b1123cfec164a133
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07495016B2

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