Bromine → HCID 11663376, 화합물

HRID 1727346

반응식

HRID 1727346 반응식
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[O:17])[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:26]Br>C(O)(=O)C>[BrH:26].[Br:26][CH:15]([C:13]1[CH:12]=[CH:11][N:10]=[C:9]([NH:8][C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH:14]=1)[C:16]([C:18]1[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=1)=[O:17]

참가 물질

4

반응물 2

HCID 24408BromineHCID 116170921-(4-Methoxyphenyl)-2-(2-tert-butoxycarbonylamino-4-pyridyl)ethanone

생성물 1

HCID 11663376HCID 11663376, 화합물수율 159.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 2-(2-tert-butoxycarbonylamino-4-pyridyl)-1-(4-methoxyphenyl)ethanone (0.36 g, 1.1 mmol) in acetic acid (5 mL) was added bromine (0.058 mL, 1.1 mmol), and the mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated, and the residue was washed with isopropyl ether to obtain a title compound (0.44 g, yield 82%).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with isopropyl ether

출처 및 근거

ORD 기록
ord-4679bfd453d644878906341df7417124
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07495018B2

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