N,N-Diethylaniline → 2,3-dihydropyrano[3,2-e]isoindol-1(7H)-one
반응식
[CH2:1]([O:4][C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][NH:10][C:11]2=[O:14])=[CH:7][CH:6]=1)[C:2]#[CH:3].C(N(CC)C1C=CC=CC=1)C>CCCCCC.CCOC(C)=O.C(Cl)Cl>[C:11]1(=[O:14])[C:12]2[C:13]3[CH:3]=[CH:2][CH2:1][O:4][C:5]=3[CH:6]=[CH:7][C:8]=2[CH2:9][NH:10]1참가 물질
4
반응 조건
- 온도
- 210 °C
실험 절차
The mixture of 6-(prop-2-ynyloxy)isoindolin-1-one ((72), 4.4 g, 23.5 mmol) and N,N-Diethylaniline 70 ml) was stirred at 210° C. for overnight. Reaction solution was directly loaded on silica gel eluting with Hexane/EtOAc/CH2Cl2 (3:3:1 ratio) to give the title compound (2.8 g, 64%) as a brown solid. MS (ES) m/z 188.1.
후처리
- customReaction solution
출처 및 근거
- ORD 기록
- ord-2f8e0f3584f44a8e80967ed562f00b55
- 출처 데이터셋
- uspto-grants-2009_02
- 특허 번호
- US07495111B2
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