Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 5-Chloro-2-(3-hydroxy-propoxy)-benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Bromo-1-propanol | HCID 12308 | — |
| 반응물 | 5-Chloro-salicylaldehyde | HCID 12481 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Chloro-2-(3-hydroxy-propoxy)-benzaldehyde | HCID 57565935 | 59% |
반응 단계
5-Chloro-2-hydroxy-benzaldehyde (3.1 g, 20 mmol), 3-bromo-propan-1-ol (4.1 mL, 24 mmol), K2CO3 (5.5 g, 4 mmol) and KI (0.5 g) were mixed in DMF (20 mL). Then the mixture was irradiated under microwave at 200° C. for 1 h. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in ethyl acetate and washed with 1N NaOH. Then the organic layer was separated, dried over Na2SO4 and concentrated to give title compound (Yield: 1.7 g, 59%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07495007B2 |
| 출처 데이터셋 | uspto-grants-2009_02 |
| ORD ID | ord-653dbb65be664e1fbbcc871c9d5ff7d6 |
| 출처 메모 | uspto-grants-2009_02 |