1,1,1-Trifluorooctan-2-YL 2-fluoro-4-hydroxybenzoate → 4-(Octyloxy)benzoic acid

HRID 1728526노트

반응식

HRID 1728526 반응식
FC1C=C(O)C=CC=1C(OC(CCCCCC)C(F)(F)F)=O.C(OC1C=C[C:35]([C:38]2C=C[C:41]([C:44]([O:46][C:47]3[CH:52]=[CH:51][C:50]([C:53]([O:55]C(CCCCCC)C(F)(F)F)=[O:54])=[C:49](F)[CH:48]=3)=O)=[CH:40][CH:39]=2)=[CH:34][CH:33]=1)CCCCCCC>O1CCCC1>[CH2:44]([O:46][C:47]1[CH:48]=[CH:49][C:50]([C:53]([OH:55])=[O:54])=[CH:51][CH:52]=1)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:35][CH2:34][CH3:33]

참가 물질

4

반응물 2

HCID 199208191,1,1-Trifluorooctan-2-YL 2-fluoro-4-hydroxybenzoateHCID 537499373-Fluoro-4-(1,1,1-trifluoro-2-octyloxycarbonyl)phenyl 4-octyloxybiphenyl-4'-carboxylate

생성물 1

HCID 172314-(Octyloxy)benzoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the 1,1,1-trifluoro-2-decyl-6-hydroxynaphthalene-2-carboxylate (0.5 g) obtained in (1) above, the 4-n-octyloxybenzoic acid (0.4 g) obtained in (2) above in tetrahydrofuran (40 ml) were added dicyclohexylcarbodiimide (0.45 g) and dimethylaminopyridine (0.05 g). The solution was stirred at room temperature overnight. The solution was distilled to remove the solvent. The residue was dissolved in dichloromethane (50 ml) and the solution was washed with dilute aqueous hydrochloric acid solution and water in this order. The organic layer collected was dried over anhydrous magnesium sulfate, and distilled to remove the solvent. The residue was purified by silica-gel column chromatography (developer: hexane/ethyl acetate=20/1) to obtain the titled compound (0.39 g) having specific rotation, [α]DD20 =+45.79°.

출처 및 근거

ORD 기록
ord-fdd2df0e504d4df08ae9aa70898a8166
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05328641

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