1,1,1-Trifluorooctan-2-YL 6-hydroxynaphthalene-2-carboxylate → Benzoic acid, 4-((1-oxodecyl)oxy)-

HRID 1728527노트

반응식

HRID 1728527 반응식
OC1C=C2C(=CC=1)C=C(C(OC(CCCCCC)C(F)(F)F)=O)C=C2.FC1C=C(O)C=CC=1C(OC(CCCCCC)C(F)(F)F)=O.C(O[C:57]1[CH:62]=C[C:60]([C:63]2C=C[C:66]([C:69]([O:71][C:72]3[CH:77]=[CH:76][C:75]([C:78]([O:80]C(CCCCCC)C(F)(F)F)=[O:79])=[C:74](F)[CH:73]=3)=[O:70])=[CH:65][CH:64]=2)=[CH:59][CH:58]=1)CCCCCCC>O1CCCC1>[CH2:66]([C:69]([O:71][C:72]1[CH:77]=[CH:76][C:75]([C:78]([OH:80])=[O:79])=[CH:74][CH:73]=1)=[O:70])[CH2:65][CH2:64][CH2:63][CH2:60][CH2:59][CH2:58][CH2:57][CH3:62]

참가 물질

5

반응물 3

HCID 157248111,1,1-Trifluorooctan-2-YL 6-hydroxynaphthalene-2-carboxylateHCID 199208191,1,1-Trifluorooctan-2-YL 2-fluoro-4-hydroxybenzoateHCID 537499373-Fluoro-4-(1,1,1-trifluoro-2-octyloxycarbonyl)phenyl 4-octyloxybiphenyl-4'-carboxylate

생성물 1

HCID 3608562Benzoic acid, 4-((1-oxodecyl)oxy)-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the 1,1,1-trifluoro-2-octyl 6-hydroxynaphthalene-2-carboxylate (0.6 g) obtained in (1) above and the 4-n-nonylcarbonyloxybenzoic acid (0.45 g) obtained in (2) above in tetrahydrofuran (40 ml) were added dicyclohexylcarbodiimide (0.45 g) and dimethylaminopyridine (0.05 g). The solution was stirred overnight and distilled to remove the solvent. The residue was dissolved in dichloromethane (40 ml) and washed with dilute aqueous hydrochloric acid solution and water, in this order. The solution was dried over anhydrous magnesium sulfate and distilled to remove the solvent. The residue was purified by silica-gel column chromatography (developer: hexane/ethyl acetate=20/1) to obtain the titled compound (0.05 g) having specific rotation, [α]D20 =+42.86°.

출처 및 근거

ORD 기록
ord-bf0e1b7dd9604ca29b4be6f68913986c
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05328641

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