4-Decanoyloxy-2-fluorobenzoic acid → 1,1,1-Trifluoro-2-decyl 4-hydroxybenzoate

HRID 1728528

반응식

HRID 1728528 반응식
F[C:2]1C=C(OC(CCCCCCCCC)=O)C=C[C:3]=1C(O)=O.C(OC1C=CC(C2C=CC(C([O:46][C:47]3[CH:52]=[CH:51][C:50]([C:53]([O:55][CH:56]([CH2:61][CH2:62][CH2:63][CH2:64][CH2:65][CH3:66])[C:57]([F:60])([F:59])[F:58])=[O:54])=[C:49](F)[CH:48]=3)=O)=CC=2)=CC=1)CCCCCCC>O1CCCC1>[OH:46][C:47]1[CH:48]=[CH:49][C:50]([C:53]([O:55][CH:56]([CH2:61][CH2:62][CH2:63][CH2:64][CH2:65][CH2:66][CH2:2][CH3:3])[C:57]([F:58])([F:59])[F:60])=[O:54])=[CH:51][CH:52]=1

참가 물질

4

반응물 2

HCID 193652624-Decanoyloxy-2-fluorobenzoic acidHCID 537499373-Fluoro-4-(1,1,1-trifluoro-2-octyloxycarbonyl)phenyl 4-octyloxybiphenyl-4'-carboxylate

생성물 1

HCID 147457541,1,1-Trifluoro-2-decyl 4-hydroxybenzoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the 2-fluoro-4-n-nonylcarbonyloxybenzoic acid (0.3 g) obtained in (3) above and the 1,1,1-trifluoro-2-decyl 4-hydroxybenzoate (0.3 g) obtained in (2) above in tetrahydrofuran (about 30 ml) were added dicyclohexylcarbodiimide (0.25 g) and dimethylaminopyridine (0.02 g). The solution was stirred at room temperature for about 20 hours. The solution was distilled to remove the solvent. The residue was dissolved in dichloromethane and washed with water. The organic layer was dried over anhydrone magnesium sulfate and distilled to remove the solvent. The residue was purified by silica-gel column chromatography (developer: hexane/ethyl acetate=20/1) to obtain the titled compound (0.21 g).

출처 및 근거

ORD 기록
ord-eaa54ae7bdf74895bf29218d0e8143c1
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05328641

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