1-Fluoro-2-methoxy-5-methyl-3-nitrobenzene → 3-Fluoro-2-methoxy-5-methylaniline

HRID 17286

반응식

HRID 17286 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[O:12][CH3:13]>[C].[Pd].CO>[F:1][C:2]1[C:3]([O:12][CH3:13])=[C:4]([CH:5]=[C:6]([CH3:8])[CH:7]=1)[NH2:9]

참가 물질

4

반응물 1

HCID 575758761-Fluoro-2-methoxy-5-methyl-3-nitrobenzene

생성물 1

HCID 451220523-Fluoro-2-methoxy-5-methylaniline수율 81.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

5% Palladium-carbon (wet, 100 mg) was added to a methanol (5 ml) solution of 1-fluoro-2-methoxy-5-methyl-3-nitrobenzene (I-25) (250 mg, 1.35 mmol), followed by stirring under hydrogen atmosphere for 30 minutes. After filtration and concentration under reduced pressure, the resulting residue was subjected to column chromatography, and the eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure to obtain the entitled compound (170 mg, 81%) as a yellow oily substance.

후처리

  1. filtrationAfter filtration and concentration under reduced pressure
  2. concentrationthe eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-51c75521558b47e6890a4a69c8e9f48b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

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