Phenylacetaldehyde → HCID 19016751, 화합물

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[N+]([O-])(O)=O.[N+:5]([O-])(O)=O.[C:9]([OH:18])(=O)[CH:10]([CH:12]([C:14]([OH:16])=[O:15])O)O.[C:19]1([CH2:25][CH:26]=O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(=O)=O.CC(C)=O.[OH-:35].[NH4+:36]>>[CH2:25]([C:26]1[NH:36][C:12]([C:14]([OH:16])=[O:15])=[C:10]([C:9]([OH:18])=[O:35])[N:5]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

반응물 4

HCID 998Phenylacetaldehyde2회

HCID 14923Ammonium Hydroxide3회

HCID 18522661Acetone cardice

HCID 86747982HCID 86747982, 화합물

생성물 1

HCID 19016751HCID 19016751, 화합물

실험 절차

Tartaric acid dinitrate (0.67 mol) was neutralized to congo red test paper with concentrated ammonium hydroxide (500 mL). Additional concentrated ammonium hydroxide (50 mL) was added followed by a phenylacetaldehyde solution [previously prepared by the careful addition of phenylacetaldehyde (3.5 mol) to concentrated ammonium hydroxide (250 mL) with ice bath cooling]. The dry ice-acetone bath was replaced with ice-water and the reaction mixture was allowed to warm to room temperature over 16 hours. The precipitate was filtered, resuspended in water (400 mL) and stirred, filtered and the solid was washed with water (3×75 mL), methanol (2×40 mL) and ether (2×40 mL), then dried under vacuum to give 2-benzyl-4,5-imidazoledicarboxylic acid.