N-Phenylglycine ethyl ester → ethyl 2-(N-phenylformamido)acetate

HRID 1728952

반응식

HRID 1728952 반응식
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].[CH:14](OC(=O)C)=[O:15]>O>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][N:6]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH:14]=[O:15])[CH3:2]

참가 물질

4

반응물 2

HCID 75190N-Phenylglycine ethyl esterHCID 75269Acetic-formic anhydride

생성물 1

HCID 14416604ethyl 2-(N-phenylformamido)acetate수율 70%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

N-Phenylglycine ethyl ester (100 g; 0-56 mol) was added in small portions to acetic formic anhydride (100 g; 1.14 mol) with vigorous stirring. The mixture was allowed to stir overnight, then it was poured into water, and extracted with ether. The ether solution was washed with sodium bicarbonate solution and then with water. The ether was evaporated in vacuo to give an oil which was distilled to give N-phenyl-N-formylglycine ethyl ester (81 g; 70%) having a bp 115°-117° C.

후처리

  1. extractionextracted with ether
  2. washThe ether solution was washed with sodium bicarbonate solution
  3. customThe ether was evaporated in vacuo
  4. customto give an oil which
  5. distillationwas distilled

출처 및 근거

ORD 기록
ord-ab70f6dde5414ecabec30cbd5dd807d6
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05329012

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