Tetrahydrofuran → 7-Bromo-6-iodo-8-methoxy-5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

HRID 17291노트

반응식

HRID 17291 반응식
[NH2:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([Br:13])[C:8]([I:14])=[C:7]([CH3:15])[C:3]=1[C:4]([OH:6])=[O:5].[O:16]1CCC[CH2:17]1>>[Br:13][C:9]1[C:8]([I:14])=[C:7]([CH3:15])[C:3]2[C:4](=[O:6])[O:5][C:17](=[O:16])[NH:1][C:2]=2[C:10]=1[O:11][CH3:12]

참가 물질

3

반응물 2

HCID 8028TetrahydrofuranHCID 860974752-Amino-4-bromo-5-iodo-3-methoxy-6-methylbenzoic Acid

생성물 1

HCID 866308077-Bromo-6-iodo-8-methoxy-5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

반응 조건

온도
40 °C

실험 절차

According to the same method as in Reference Example 31, 2-amino-4-bromo-5-iodo-3-methoxy-6-methylbenzoic acid (I-4) (3.42 g, 8.86 mmol) and bis(trichloromethyl) carbamate (893 mg, 3.01 mmol) were dissolved in dewatered tetrahydrofuran (70 ml) under nitrogen atmosphere, followed by stirring at 40° C. for 1 hour. The reaction liquid was concentrated under reduced pressure to obtain the entitled compound (3.89 g, quant.) as a pale brown solid. Not further purified, this was used in the next reaction.

후처리

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. customto obtain the entitled compound (3.89 g, quant.) as a pale brown solid
  4. customNot further purified
  5. customthis was used in the next reaction

출처 및 근거

ORD 기록
ord-e6864ecd40904878b728d64c6b38f328
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

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