참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Benzamide | HCID 2331 | — |
| 반응물 | 4'-Nitrobenzanilide | HCID 76930 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Nitroaniline | HCID 7475 | 50% |
반응 단계
Approximately 10 ml of liquid ammonia was added rapidly to a solution of 100 mg of 4'-nitrobenzanilide and 50 ml of methanol in a Parr bomb at -50° C. The Parr reactor was stirred at 120° C./300 psi (21.1 kg/cm2) for 3 days. After the reactor was cooled to -50°C., the pressure was released and the reactor was opened. An aliquot was taken out for HPLC analysis which revealed a 50% yield of 4-nitroaniline and benzamide. The remainder of the material was unreacted.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05331099 |
|---|
| 출처 데이터셋 | uspto-grants-1994_07 |
|---|
| ORD ID | ord-c9dcf08f15d24adda6480693506c057c |
|---|
| 출처 메모 | uspto-grants-1994_07 |
|---|
