Bromine → 4-(2',4'-Dichlorophenyl)-5-methylthiazole hydrobromide

HRID 1729272노트

반응식

HRID 1729272 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[CH2:10][CH3:11].[Br:13]Br.[CH:15]([NH2:17])=[S:16]>C(Cl)Cl>[BrH:13].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:17]=[CH:15][S:16][C:10]=1[CH3:11]

참가 물질

5

반응물 3

HCID 24408BromineHCID 1234672',4'-DichloropropiophenoneHCID 3005587Methanethioamide

생성물 1

HCID 190124704-(2',4'-Dichlorophenyl)-5-methylthiazole hydrobromide수율 53%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
20 °C

실험 절차

To 2',4'-dichloropropiophenone (2.03 g; 0.01 mole) in methylene chloride (20 ml) was added excess bromine in methylene chloride (10 ml) dropwise at 20° C. The methylene chloride layer was washed with sodium sulphite solution and water, separated, dried (MgSO4) and evaporated. The residue was dissolved in ethanol (20 ml) and thioformamide (0.61 g; 0.01 mole) was added and the mixture stirred at 20° C. for 16 hours to give 4-(2',4'-dichlorophenyl)-5-methylthiazole hydrobromide (1.72 g; 53%).

후처리

  1. washThe methylene chloride layer was washed with sodium sulphite solution and water
  2. customseparated
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. dissolutionThe residue was dissolved in ethanol (20 ml)

출처 및 근거

ORD 기록
ord-710cdbd9ed75436bbc898ae53e73aa5c
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05332753

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