Isopropanol → HCID 21498784, 화합물

HRID 1729989노트

반응식

HRID 1729989 반응식
C([N:9]1[CH2:18][C:17]2[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[C:12]=2[CH2:11][CH2:10]1)(=O)C1C=CC=CC=1.CC(O)C>O.OS(O)(=O)=O>[CH2:11]1[CH2:10][NH:9][CH2:18][C:17]2[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[C:12]1=2

참가 물질

5

반응물 2

HCID 3776IsopropanolHCID 214987793-Benzoyl-2,3,4,6-tetrahydrobenzo[c][2,7]naphthyridin-5(1H)-one

생성물 1

HCID 21498784HCID 21498784, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 1118Sulfuric Acid용매2회

실험 절차

A solution of 7.7 g (0.025 m) of 3-benzoyl-1,2,3,4-tetrahydrobenzo[c][2,7]naphthyridin-5(6H)-one in 30 ml of water, 10 ml of H2SO4, and 200 ml of 2-propanol was refluxed for 20 hr. After cooling, the solid was filtered and recrystallized from water, mp 292°-295° C. By analysis, this material contains 0.7 mole of H2SO4 per mole of base and was used as is for alkylation.

후처리

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered
  3. customrecrystallized from water, mp 292°-295° C

출처 및 근거

ORD 기록
ord-a5f8355d9316499f8b0646878de3c3ca
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03991064

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