Imidazole → 1-[N-2-chlorophenyl-N-propyl (thiocarbamoyl)]imidazole

HRID 1730027노트

반응식

HRID 1730027 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:12][CH2:13][CH3:14])[C:9](Cl)=[S:10].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:12][CH2:13][CH3:14])[C:9]([N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[S:10]

참가 물질

4

반응물 2

HCID 795Imidazole2회HCID 21319512Carbamothioic chloride, (2-chlorophenyl)propyl-

생성물 1

HCID 542482291-[N-2-chlorophenyl-N-propyl (thiocarbamoyl)]imidazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

12.4 g. N-2-chlorophenyl-N-propyl(thiocarbamoyl) chloride and 6.8 g. imidazole were refluxed in 75 ml. dry tetrahydrofuran for 16 hours. A further 2 g. imidazole was then added and the heating continued for 8 hours. After separating the solid formed evaporation of the tetrahydrofuran left an oil which was dissolved in methylene chloride. The resulting organic phase was washed with water, dried with soldium sulphate and the solvent evaporated to leave an oil which crystallised on treatment with light petroleum and chilling to give the product, 1-[N-2-chlorophenyl-N-propyl (thiocarbamoyl)]imidazole, m.p. 59°-61° C.

후처리

  1. customAfter separating the solid
  2. customformed
  3. customevaporation of the tetrahydrofuran
  4. waitleft an oil which
  5. dissolutionwas dissolved in methylene chloride
  6. washThe resulting organic phase was washed with water
  7. dry with materialdried with soldium sulphate
  8. customthe solvent evaporated
  9. customto leave an oil which
  10. customcrystallised on treatment with light petroleum
  11. temperaturechilling

출처 및 근거

ORD 기록
ord-78dcce6112dc4e2aaeb2b09ec17d2b79
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03991071

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