Ethyl 7-bromoheptanoate → 7-{N-[4-hydroxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoic Acid

HRID 1730128노트

반응식

HRID 1730128 반응식
C([O:4][CH:5]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[C:6]#[C:7][CH2:8][NH:9][S:10]([CH3:13])(=[O:12])=[O:11])(=O)C.C(OC(COC1C=CC(F)=CC=1)CCCNS(C)(=O)=O)(=O)C.Br[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][C:52]([O:54]CC)=[O:53].BrCC#CCCCC(OCC)=O>>[OH:4][CH:5]([CH2:14][O:15][C:16]1[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=1)[C:6]#[C:7][CH2:8][N:9]([CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][C:52]([OH:54])=[O:53])[S:10]([CH3:13])(=[O:11])=[O:12]

참가 물질

5

반응물 4

HCID 122490Ethyl 7-bromoheptanoateHCID 15174663Ethyl 7-bromohept-5-ynoateHCID 21401584N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamideHCID 21401585HCID 21401585, 화합물

생성물 1

HCID 214015787-{N-[4-hydroxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoic Acid

실험 절차

This compound is prepared by the procedure described in Example 2, Step I, except that N-[4-acetoxy-5-(4-fluorophenoxy)- 2-pentynyl]methanesulfonamide is substituted for the N-[4-acetoxy-5-(4-fluorophenoxy)pentyl]methanesulfonamide and ethyl 7-bromoheptanoate is substituted for ethyl 7-bromo-5-heptynoate. The product is thus ethyl 7-{N-[4 -acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamide} -heptanoate. The subsequent hydrolysis (Example 2, Step J) affords the subject compound.

후처리

  1. customThis compound is prepared by the procedure
  2. customThe subsequent hydrolysis (Example 2, Step J)
  3. customaffords the subject compound

출처 및 근거

ORD 기록
ord-3ce367539afe4eb78136e1b9ac559d95
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03991106

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