1,4-Dioxane → 2-[2-(2,2-Diethoxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

HRID 1730192

반응식

HRID 1730192 반응식
OCCN[N:5]1[NH:9][CH:8]=[C:7]([C:10]2[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=2)[S:6]1.[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH2:24])[CH3:20].O1CCOCC1>O>[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH:24][N:5]1[NH:9][CH:8]=[C:7]([C:10]2[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=2)[S:6]1)[CH3:20]

참가 물질

5

반응물 3

HCID 312751,4-DioxaneHCID 695242,2-DiethoxyethylamineHCID 213908472-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

생성물 1

HCID 213908052-[2-(2,2-Diethoxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture composed of 9.8 g. of 2-(2-chloro-5-thiadiazole)-1-methyl-5-nitroimidazole, (Example 16), 11.0 g. of 2,2-diethoxyethylamine, and 250 ml. of dioxane is stirred and heated on the steam bath for 12 hours. It is then diluted with 500 ml. of cold water, cooled, and the precipitated yellow solid collected and dried. Recrystallization from 50% aqueous ethanol gives the pure compound melting at 154°-155° C.

후처리

  1. temperatureheated on the steam bath for 12 hours
  2. additionIt is then diluted with 500 ml
  3. customthe precipitated yellow solid collected
  4. customdried
  5. customRecrystallization from 50% aqueous ethanol

출처 및 근거

ORD 기록
ord-55998eae4d09467f9b4e4fd38f184870
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03991200

연결된 노트

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