Piperidine → 2-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

HRID 1730193

반응식

HRID 1730193 반응식
O[CH2:2][CH2:3][NH:4][N:5]1[NH:9][CH:8]=[C:7]([C:10]2[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=2)[S:6]1.N1CC[CH2:22][CH2:21][CH2:20]1>O1CCOCC1>[N:4]1([N:5]2[NH:9][CH:8]=[C:7]([C:10]3[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=3)[S:6]2)[CH2:22][CH2:21][CH2:20][CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 213908472-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

생성물 1

HCID 213908372-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture composed of 7.4 g. of 2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole (Example 16), 6 g. of piperidine, and 200 ml. of dioxane is stirred at room temperature for 24 hours, and then taken to dryness under reduced pressure. The residue is shaken with 100 ml. of water and the insoluble portion collected and dried. Recrystallization from 150 ml. of 2-methoxyethanol gives 7.6 g. of the subject compound melting at 212°-213° C.

후처리

  1. customof water and the insoluble portion collected
  2. customdried
  3. customRecrystallization from 150 ml
  4. customof 2-methoxyethanol gives 7.6 g

출처 및 근거

ORD 기록
ord-a64f79b2242147d0be74e6c65307ee30
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03991200

연결된 노트

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