Potassium Carbonate → 1-[2-(3,4-Dichlorophenyl)ethyl]-4-benzamidopiperidine

HRID 1730347노트

반응식

HRID 1730347 반응식
[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:22][C:23]1[CH:24]=[C:25]([CH2:30][CH2:31]Br)[CH:26]=[CH:27][C:28]=1[Cl:29]>>[Cl:22][C:23]1[CH:24]=[C:25]([CH2:30][CH2:31][N:13]2[CH2:14][CH2:15][CH:10]([NH:9][C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:11][CH2:12]2)[CH:26]=[CH:27][C:28]=1[Cl:29]

참가 물질

4

반응물 3

HCID 11430Potassium CarbonateHCID 118120N-4-PiperidylbenzamideHCID 151493894-(2-Bromoethyl)-1,2-dichlorobenzene

생성물 1

HCID 214132531-[2-(3,4-Dichlorophenyl)ethyl]-4-benzamidopiperidine수율 94.2%

반응 조건

온도
100 °C

실험 절차

4-Benzamidopiperidine (204 mg.) and anhydrous potassium carbonate (138 mg.)were intimately ground together and added to 2-(3,4-dichlorophenyl)ethyl bromide (254 mg.). The resulting paste was heated at 100° C for 2 hours to give a hard solid. This was broken up, washed well with water andether and dried to give the title compound (355 mg.). Recrystallisation from ethanolic hydrogen chloride and ether gave the hydrochloride (237 mg.), m.p. 286.0° C. (Found: C, 58.2; H, 5.8; N, 6.8. C20H22Cl2N2O.HCl requires C, 58.05; H, 5.6; N, 6.8%).

후처리

  1. customto give a hard solid
  2. washwashed well with water andether
  3. customdried

출처 및 근거

ORD 기록
ord-dc49b45bbee1484b94c8efa1040cbaa0
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03992389

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