Trifluoroacetic acid → HCID 21498242, 화합물

반응식

[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[F:15][C:16]([F:21])([F:20])[C:17](O)=O>>[F:15][C:16]([F:21])([F:20])[C:17]1[N:4]2[CH:5]=[CH:6][C:7]3[C:12]([C:3]2=[N:1][N:2]=1)=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=3

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 214982201-Hydrazinyl-7-methoxyisoquinoline

생성물 1

HCID 21498242HCID 21498242, 화합물수율 70%

실험 절차

A solution of 1-hydrazino-7-methoxyisoquinoline in excess trifluoroacetic acid was allowed to reflux for 2 hours. Excess acid was removed in vacuo and the residue was slurried in water and treated with sodium bicarbonate solution. The solid was removed by filtration and recrystallized from cyclohexane to give the product in a yield of 70%; m.p. 152°-154°C.

후처리

temperatureto reflux for 2 hours
customExcess acid was removed in vacuo
additiontreated with sodium bicarbonate solution
customThe solid was removed by filtration
customrecrystallized from cyclohexane
customto give the product in a yield of 70%

출처 및 근거

ORD 기록: ord-cb8697c9166b4b75ada6cfd0dbd95a89
출처 데이터셋: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US03992539

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