2-Chloro-4-(chlorosulfonyl)benzoic acid → rel-2-Chloro-5-(((3R,5S)-3,5-dimethyl-1-piperidinyl)sulfonyl)benzoic acid

HRID 1730587

반응식

HRID 1730587 반응식
ClC1C=C([S:11]([N:14]2[CH2:19][C@H:18]([CH3:20])[CH2:17][C@H:16]([CH3:21])[CH2:15]2)(=[O:13])=[O:12])C=CC=1C(O)=O.[Cl:22][C:23]1[CH:31]=[C:30](S(Cl)(=O)=O)[CH:29]=[CH:28][C:24]=1[C:25]([OH:27])=[O:26]>>[Cl:22][C:23]1[CH:31]=[CH:30][C:29]([S:11]([N:14]2[CH2:19][C@H:18]([CH3:20])[CH2:17][C@H:16]([CH3:21])[CH2:15]2)(=[O:12])=[O:13])=[CH:28][C:24]=1[C:25]([OH:27])=[O:26]

참가 물질

3

반응물 2

HCID 1884272-Chloro-4-(chlorosulfonyl)benzoic acidHCID 544445592-Chloro-4-(cis-3,5-dimethylpiperidinosulfonyl)benzoic acid

생성물 1

HCID 32335rel-2-Chloro-5-(((3R,5S)-3,5-dimethyl-1-piperidinyl)sulfonyl)benzoic acid

실험 절차

In the same way, 2-chloro-4-(cis-3,5-dimethylpiperidinosulfonyl)benzoic acid, m.p. 233°-234° C., is prepared from 2-chloro-4-chlorosulfonylbenzoic acid.

출처 및 근거

ORD 기록
ord-bc343ccda82340e6bd33f65c202e643d
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03992441

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