P-Nitrobenzotrifluoride → 4-(Trifluoromethyl)aniline

HRID 1730725

반응식

HRID 1730725 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 9821P-NitrobenzotrifluorideHCID 178418361HCID 178418361, 화합물3회

생성물 1

HCID 99644-(Trifluoromethyl)aniline수율 94%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

160 Parts of p-nitrobenzotrifluoride is dissolved in 500 parts of ethanol and 1 part platinum oxide catalyst is added. The mixture is placed in a pressure vessel and hydrogen is added at a temperature of 30° C and a pressure of 13.6 atmospheres. The hydrogen pressure is increased to 34 atmospheres during the course of the reaction, which continues until the hydrogen uptake ceases. The excess hydrogen is removed from the reaction vessel under reduced pressure and the catalyst is removed from the mixture by filtration. The solvent is removed from the filtrate under reduced pressure to give 127 parts (94% yield) of p-aminobenzotrifluoride.

후처리

  1. additionis added
  2. customThe mixture is placed in a pressure vessel
  3. customThe excess hydrogen is removed from the reaction vessel under reduced pressure
  4. customthe catalyst is removed from the mixture by filtration
  5. customThe solvent is removed from the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-e5ee7aa95bfb4b2e810bd372dbe797f9
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03993704

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