Trifluoroacetic acid → alpha-[(Thioxomethyl)amino]benzeneacetic acid

HRID 1730858노트

반응식

HRID 1730858 반응식
[S:1]=[CH:2][NH:3][CH:4]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:5]([O:7]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:6].FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>>[S:1]=[CH:2][NH:3][CH:4]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:5]([OH:7])=[O:6]

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 14447407HCID 14447407, 화합물

생성물 1

HCID 21492714alpha-[(Thioxomethyl)amino]benzeneacetic acid

실험 절차

3.61 g. (0.01 mol.) of α-[(thioxomethyl)amino]-benzeneacetic acid, diphenylmethyl ester are added to a mixture of 30 ml. of trifluoroacetic acid and 5 ml. of anisole at 0°-5° and the mixture is stirred for ten minutes. The mixture is concentrated, sodium bicarbonate solution is added to the residue and the aqueous phase is extracted with ether. This is then layered over with fresh ether, acidified and the aqueous phase is extracted twice with ether. Concentration of the ether solution yields α-[(thioxomethyl)amino]benzeneacetic acid as an oily residue.

후처리

  1. concentrationThe mixture is concentrated
  2. additionsodium bicarbonate solution is added to the residue
  3. extractionthe aqueous phase is extracted with ether
  4. extractionthe aqueous phase is extracted twice with ether

출처 및 근거

ORD 기록
ord-a642de4751af44089f5e93ca18c27aca
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03994889

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