Diphenic anhydride → 2'-[[[3-(4-Phenyl-1-piperidinyl)propyl]amino]-carbonyl][1,1'-biphenyl]-2-carboxylic acid

참여 물질

반응 단계

4-Phenyl-1-piperidinepropanamine, hydrochloride (prepared in part A) (16.33 g, 53.5 mM) and diphenic anhydride (12.0 g, 53.5 mM) are refluxed in toluene for 2 hours. The mixture is allowed to stand overnight at room temperature during which time product crystallizes out. The crystals are filtered off, washed with toluene, recrystallized from ethanol, and dried at 80° to give the title compound.

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