Water → 3-(3'-Cyano-2'-hydroxypropyl)-benzophenone

HRID 1731175

반응식

HRID 1731175 반응식
[C:1]([CH2:3][CH:4]([OH:20])[CH2:5][C:6]1[CH:7]=[C:8]([CH:17]=[CH:18][CH:19]=1)[CH:9]([OH:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)#[N:2].O>CC(C)=O>[C:1]([CH2:3][CH:4]([OH:20])[CH2:5][C:6]1[CH:7]=[C:8]([CH:17]=[CH:18][CH:19]=1)[C:9]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[O:16])#[N:2]

참가 물질

4

반응물 2

HCID 962WaterHCID 214956743-(3'-Cyano-2'-hydroxypropyl)-benzhydrol

생성물 1

HCID 214956823-(3'-Cyano-2'-hydroxypropyl)-benzophenone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

7.35 ml of a sulfochromic mixture titrating 26.5 g of chromic anhydride per 100 ml was added with stirring at 0° C to 7.8 g of 3-(3'-cyano-2'-hydroxypropyl)-benzhydrol in 78 ml of acetone and the mixture was allowed to stand at 0° C for 5 minutes and was then poured into water with stirring. The mixture was extracted with methylene chloride and the organic phase was washed with water, dried over sodium sulfate, treated with activated carbon, filtered and evaporated to dryness to obtain 7.4 g of 3-(3'-cyano-2'-hydroxypropyl)-benzophenone which was used as is for the next step.

후처리

  1. additionwas added
  2. extractionThe mixture was extracted with methylene chloride
  3. washthe organic phase was washed with water
  4. dry with materialdried over sodium sulfate
  5. additiontreated with activated carbon
  6. filtrationfiltered
  7. customevaporated to dryness

출처 및 근거

ORD 기록
ord-6c4ba07f63d34ae8a577bcef1b5fcec4
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03995056

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