2-Aminopyridine → HCID 20228714, 화합물

반응식

Br[CH:2]([CH3:18])[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:13][CH:12]([CH2:14][CH3:15])[C:11](=[O:16])[NH:10][C:9]=2[CH:17]=1)=O.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1>>[CH3:18][C:2]1[N:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]2=[N:19][C:3]=1[C:5]1[CH:6]=[CH:7][C:8]2[O:13][CH:12]([CH2:14][CH3:15])[C:11](=[O:16])[NH:10][C:9]=2[CH:17]=1

참가 물질

반응물 2

HCID 104392-Aminopyridine

HCID 202286796-(2-Bromopropanoyl)-2-ethyl-2H-1,4-benzoxazin-3(4H)-one

생성물 1

HCID 20228714HCID 20228714, 화합물수율 47.7%

실험 절차

6-(3-Methylimidazo[1,2-a]pyridin-2-yl)-2-ethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (1.07 g) was prepared in substantially the same manner as that of Example 16 from 6-(2-bromopropionyl)-2-ethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (2.28 g) and 2-aminopyridine (2.0 g).

출처 및 근거

ORD 기록: ord-229dab7d49984a87aa35b5acfbb62cf7
출처 데이터셋: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04621084

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