Water → HCID 178509797, 화합물

HRID 1731434노트

반응식

HRID 1731434 반응식
C[O:2][CH:3]=[CH:4][CH2:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1.O>O1CCCC1>[C:16]([C:15]1[CH:18]=[CH:19][C:12]([C@H:9]2[CH2:10][CH2:11][C@H:6]([CH2:5][CH2:4][CH:3]=[O:2])[CH2:7][CH2:8]2)=[CH:13][CH:14]=1)#[N:17]

참가 물질

4

반응물 2

HCID 962WaterHCID 178495003HCID 178495003, 화합물

생성물 1

HCID 178509797HCID 178509797, 화합물수율 99%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2.04 g of p-[trans-4-(3-methoxy-2-propenyl)cyclohexyl]benzonitrile in 100 ml of tetrahydrofuran/2N hydrochloric acid (vol. 4:1) was heated to reflux for 1 hour. The reaction mixture was subsequently poured into 100 ml of water and extracted three times with 100 ml of diethyl ether each time. The organic phases were washed twice with 100 ml of water each time, dried over magnesium sulphate and concentrated, whereby 1.9 g (99%) of 3-[trans-4-(p-cyanophenyl)cyclohexyl]propionaldehyde were obtained as colourless crystals; Rf-value (ethyl acetate/petroleum ether vol. 10:90) 0.15.

후처리

  1. temperatureto reflux for 1 hour
  2. extractionextracted three times with 100 ml of diethyl ether each time
  3. washThe organic phases were washed twice with 100 ml of water each time
  4. dry with materialdried over magnesium sulphate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-34293fab57a2438ab61334a80c3b2369
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04621901

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