Water → 1-Amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane

HRID 1731505노트

반응식

HRID 1731505 반응식
C([NH:8][C:9]1([C:12]([CH:14]2[C:18]([CH3:20])([CH3:19])[CH2:17][CH2:16][C:15]2([CH3:22])[CH3:21])=[CH2:13])[CH2:11][CH2:10]1)(OC(C)(C)C)=O.O.[OH-].[K+]>FC(F)(F)C(O)=O>[NH2:8][C:9]1([C:12]([CH:14]2[C:18]([CH3:20])([CH3:19])[CH2:17][CH2:16][C:15]2([CH3:22])[CH3:21])=[CH2:13])[CH2:11][CH2:10]1

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 70445455N-Boc-1-amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane

생성물 1

HCID 201644421-Amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

N-Boc-1-amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane is dissolved in trifluoroacetic acid and the solution is stirred overnight. Water is added and the mixture is made basic with 20% KOH. The mixture is extracted with ether, and the organic layer is dried over Na2SO4 and is evaporated to yield 1-amino-1-(2,2,5,5-tetramethyl-1-cyclopentyl)ethenylcyclopropane.

후처리

  1. extractionThe mixture is extracted with ether
  2. dry with materialthe organic layer is dried over Na2SO4
  3. customis evaporated

출처 및 근거

ORD 기록
ord-69333c8a77b7442a88b66125c67e1fce
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04622232

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