Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(p-Methoxyphenyl)-2-propanone → N-[2-(4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-fluorophenyl)ethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(p-Methoxyphenyl)-2-propanone | HCID 31231 | — |
| 반응물 | 2-Amino-1-(3-fluorophenyl)ethan-1-ol | HCID 35800 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 생성물 | N-[2-(4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-fluorophenyl)ethanamine | HCID 20227980 | — |
반응 단계
1-(4-Methoxyphenyl)propan-2-one (2.25 g) and 2-hydroxy-2-(3-fluorophenyl)ethanamine (2.13 g) were condensed ahd subsequently reduced with sodium borohydride (2.75 g) by an analogous procedure to that described in Example 1. The crude product was recrystallised from diethyl ether-hexane to give N-[2-(4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-fluorophenyl)ethanamine, mp 85°-9° C., as a 37:63 mixture of diastereoisomers.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04622342 |
| 출처 데이터셋 | uspto-grants-1986_11 |
| ORD ID | ord-2b38915ea92c4bc7bb59a6862849825d |
| 출처 메모 | uspto-grants-1986_11 |