Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Choline → 1-(Benzo[d]thiazol-2-yl)-4,5-dihydro-1H-pyrazol-3-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Choline | HCID 305 | — |
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 2-Benzothiazolinone, hydrazone | HCID 11988 | — |
| 반응물 | Propanenitrile, 3-ethoxy- | HCID 16501 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-(Benzo[d]thiazol-2-yl)-4,5-dihydro-1H-pyrazol-3-amine | HCID 20228180 | — |
반응 단계
A mixture of 5.0 g. of β-ethoxypropionitrile, 100 ml. of absolute ethanol, 8.25 g. of 2-hydrazinobenzothiazole and 2.5 g. of 50% w/v choline in methanol is refluxed on a steam bath for 16 hours, then the solvent is removed in vacuo. Water is added and the solid is collected by filtration. The solid is recrystalized twice from ethanol to give 5.75 g. of the product of the Example as grey prisms, m.p. 231.5°-235° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04622401 |
| 출처 데이터셋 | uspto-grants-1986_11 |
| ORD ID | ord-96eb4ec0f63c4844ba66b37c8d009237 |
| 출처 메모 | uspto-grants-1986_11 |