HCID 14010268, 화합물 → HCID 19863758, 화합물

HRID 1731773노트

반응식

HRID 1731773 반응식
[ClH:1].[CH:2](=[N:9][CH2:10][CH2:11][NH:12][S:13]([N:16]([CH3:18])[CH3:17])(=[O:15])=[O:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H][H]>CO.[Pd]>[ClH:1].[CH2:2]([NH:9][CH2:10][CH2:11][NH:12][S:13]([N:16]([CH3:18])[CH3:17])(=[O:15])=[O:14])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 14010268HCID 14010268, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 19863758HCID 19863758, 화합물수율 92.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 3.0 g (0.011 mole) of N-benzylidene-2-[N'-[(dimethylamino)sulfonyl]amino]ethylamine hydrochloride in 100 ml of methanol was hydrogenated, at 40 psi, over 0.3 g of 10% Pd-C catalyst until hydrogen uptake ceased (20 min.). The mixture was filtered and concentrated under reduced pressure to provide 3.0 g of crude product. The NMR spectrun was consistent with the assigned structure and the crude product was utilized directly without further purification.

후처리

  1. custom(20 min.)
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a3ed332751754a06bb2a04bb776f2e71
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04623652

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