N-Butylbenzylamine → N-Benzyl-N-butyl-N'-(3-chlorophenyl)urea

HRID 1731834노트

반응식

HRID 1731834 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:17])OC2C=CC=CC=2)[CH:5]=[CH:6][CH:7]=1.[CH2:18]([NH:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O1CCCC1.CCCCCC>[CH2:18]([N:25]([CH2:26][CH2:27][CH2:28][CH3:29])[C:9]([NH:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)=[O:17])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 2

HCID 75467N-ButylbenzylamineHCID 232110Phenyl hydrogen (3-chlorophenyl)carbonimidate

생성물 1

HCID 13733049N-Benzyl-N-butyl-N'-(3-chlorophenyl)urea

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8058Hexane용매

실험 절차

A solution of 1.46 g of phenyl N-(3-chlorophenyl)carbamate in 15 ml of tetrahydrofuran was added to a solution of 1.92 g of N-benzyl-n-butylamine in 20 ml of tetrahydrofuran and the mixture stirred under reflux for 24 hours. The mixture was diluted with hexane and the precipitate collected by filtration. Recrystallization from pentane afforded 1-benzyl-1-(n-butyl)-3-(3-chlorophenyl)urea, m.p. 69°-70° C.

후처리

  1. temperatureunder reflux for 24 hours
  2. filtrationthe precipitate collected by filtration
  3. customRecrystallization from pentane

출처 및 근거

ORD 기록
ord-b2531c9fc7a9451e8ef34dde53f31da5
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04623662

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