Dimethylamine → 1-ethyl-N,N-dimethyl[1,2,4]triazolo[4,3-a]quinoxalin-4-amine

HRID 1731940노트

반응식

HRID 1731940 반응식
Cl[C:2]1[C:3]2[N:4]([C:12]([CH2:15][CH3:16])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:17][NH:18][CH3:19]>CN(C)C=O>[CH3:17][N:18]([CH3:19])[C:2]1[C:3]2[N:4]([C:12]([CH2:15][CH3:16])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 133857064-Chloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline

생성물 1

HCID 8992951-ethyl-N,N-dimethyl[1,2,4]triazolo[4,3-a]quinoxalin-4-amine수율 42%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Chloro-1-ethyl-[1,2,4]triazolo-[4,3-a]quinoxaline (1.2 g., 0.005 mole), the product of Example 4, and 676 mg. (0.015 mole) of anhydrous dimethylamine in N,N-dimethylformamide (50 ml.) were stirred at 0° C. for 30 minutes and at room temperature for 2 hours. The reaction mixture was poured over ice and stirred for 20 minutes. The precipitate which formed was separated by filtration, washed with water and air dried. Recrystallization from chloroform and then from chloroform/cyclohexane afforded 510 mg. (42% yield) of 4-dimethylamino-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 155°-8° C.

후처리

  1. additionThe reaction mixture was poured over ice
  2. customThe precipitate which formed
  3. customwas separated by filtration
  4. washwashed with water and air
  5. customdried
  6. customRecrystallization from chloroform
  7. customfrom chloroform/cyclohexane afforded 510 mg

출처 및 근거

ORD 기록
ord-f438f51f835b4a998c6c758a71ce919f
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04623725

반응 노트

불러오는 중…