Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trichloroacetic Acid → ASTA-Z-7654(free acid)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trichloroacetic Acid | HCID 6421 | — |
| 반응물 | 4-Hydroxycyclophosphamide | HCID 99735 | — |
| 반응물 | 2-Sulfanylethane-1-sulfonic acid--cyclohexanamine (1/1) | HCID 23049873 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | ASTA-Z-7654(free acid) | HCID 6917796 | — |
반응 단계
5.6 g (20 mmol) of 4-hydroxycyclophosphamide (i.e., 2-(bis (2-chloroethyl)-amino)-4-hydroxy-tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide) and 4.8 g (20 mmol) of cyclohexylammonium-2-mercaptoethanesulphonate were dissolved in 100 ml of distilled water, mixed with some trichloroacetic acid and left to stand in a refrigerator for 3 days at 0° C. The solvent was then removed under high vacuum, the residue was taken up in acetone, re-concentrated, crystallised from acetone and recrystallised from isopropanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04623742 |
| 출처 데이터셋 | uspto-grants-1986_11 |
| ORD ID | ord-afb7b71757f1405a82a4511a524d9fbf |
| 출처 메모 | uspto-grants-1986_11 |